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Infectious Disease: Tuberculosis

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Total 35529 results found since Jan 2013.

Clinical profile of acute kidney injury in a pediatric intensive care unit from Southern India: A prospective observational study
Conclusions: Besides the high incidence of AKI in critically ill-children admitted to the PICU (25.1%), the condition was associated with adverse outcomes, including high mortality (46.3%) and need for dialysis (27.8%). Infections dominated the etiological profile. Requirement of mechanical ventilation predicted an adverse outcome in our patient population.
Source: Indian Journal of Critical Care Medicine - September 19, 2013 Category: Intensive Care Authors: Sriram KrishnamurthyParameswaran NarayananSivaprakasam PrabhaNivedita MondalSubramanian MahadevanNiranjan BiswalSadagopan Srinivasan Source Type: research

Profile of patients with active tuberculosis admitted to a respiratory intensive care unit in a tertiary care center of North India
Conclusion: TB was an uncommon cause of ICU admission even in a high TB burden country. Critically ill patients with TB had high mortality. A higher APACHE II score and delta SOFA were independent predictors of ICU mortality.
Source: Indian Journal of Critical Care Medicine - February 19, 2018 Category: Intensive Care Authors: Valliappan Muthu Sahajal Dhooria Ritesh Agarwal Kuruswamy Thurai Prasad Ashutosh N Aggarwal Digambar Behera Inderpaul Singh Sehgal Source Type: research

Coinfections in Intensive Care Unit with pulmonary tuberculosis and mucormycosis: A clinical dilemma
Pratibha Dube, Richa Saroa, Sanjeev PaltaIndian Journal of Critical Care Medicine 2016 20(3):191-193Herein, we present the case report of an adult male diabetic patient who had coinfection with Mycobacterium tuberculosis and mucormycosis, which otherwise is a rare clinical entity. Diabetes mellitus may predispose a patient to tuberculosis (TB) infection which further weakens immune system thus making him susceptible to other fungal or bacterial infections which may pose various treatment difficulties. Therefore, there is a need for mycological and bacteriological investigations in patients with pulmonary TB to rule out sec...
Source: Indian Journal of Critical Care Medicine - March 8, 2016 Category: Intensive Care Authors: Pratibha DubeRicha SaroaSanjeev Palta Source Type: research

Cerebral salt wasting in pediatric critical care; not just a neurosurgical disorder anymore.
CONCLUSION: Cerebral salt-wasting syndrome is increasingly described in the etiology of hyponatremia that is commonly seen in children hospitalized especially at critical care units. Serum sodium, urinary sodium and polyuria should be primarily considered in the diagnosis, and supportive laboratory tests such as uric acid and brain natriuretic peptide (BNP) should not be stipulated. At hospitals providing inpatient care services, clinical and laboratory characteristics of CSWS should be known in detail especially at pediatric critical care units. PMID: 26812288 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - January 28, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Severe Mycobacterium tuberculosis-related immune reconstitution syndrome in an immunocompetent patient
We present a young immunocompetent male with diagnosed sputum culture-positive tuberculosis on intensive phase with observed daily four-drug antituberculosis therapy. He presented at 1-month of treatment with sequential bilateral pneumothoraces, increase in cavitation and consolidation and respiratory failure. Repeat smears for acid-fast bacilli had downgraded, and cultures were negative. Quantiferon-GOLD (initially negative) was now strongly positive. A diagnosis of possible immune reconstitution syndrome was considered and 0.25 mg/kg/day oral steroids administered. We also discuss an approach to differential diagnosis of...
Source: Indian Journal of Critical Care Medicine - January 6, 2015 Category: Intensive Care Authors: Srinivas RajagopalaSujatha Chandrasekharan Source Type: research

Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease.
PMID: 25978571 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Voskuil MI, Schlesinger LS Tags: Am J Respir Crit Care Med Source Type: research

A rare case of idiopathic cluster of differentiation 4 + T-cell lymphocytopenia presenting with disseminated tubercular infection
We present a case of disseminated tuberculosis with low CD4 counts without any evidence of HIV infection.
Source: Indian Journal of Critical Care Medicine - October 9, 2015 Category: Intensive Care Authors: Vikas SikriHarpreet KaurAlok Jain Source Type: research

Moving Toward Tuberculosis Elimination: Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.
P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P Abstract Tuberculosis (TB) has surpassed HIV to become the leading infectious killer of adults globally, causing almost 2 million deaths annually. Although this airborne disease has been treatable since 1948, global rates of TB have dropped less than two percent per year; an estimated 10 million incident cases continue to occur annually, including one million in children. While transmission of active disease is an important driver of the epidemic, the seedbed that feeds the epidemic is the more than two billion pe...
Source: American Journal of Respiratory and Critical Care Medicine - October 18, 2018 Category: Respiratory Medicine Authors: Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame Tags: Am J Respir Crit Care Med Source Type: research

The Epidemiological Importance of Subclinical Tuberculosis: A Critical Re-Appraisal.
Abstract Subclinical tuberculosis includes disease forms that are detectable by radiographic or microbiological assays but do not cause recognizable symptoms. Population-based prevalence surveys demonstrate that the majority of individuals with culture-positive tuberculosis and corresponding radiographic abnormalities lack recognizable symptoms. Subclinical tuberculosis is often conceptualized as an early stage that generally progresses to recognizable active tuberculosis disease within months. However, many individuals with subclinical tuberculosis likely never develop recognizable symptoms, and consequently are ...
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2020 Category: Respiratory Medicine Authors: Kendall EA, Shrestha S, Dowdy DW Tags: Am J Respir Crit Care Med Source Type: research

Making Tuberculosis Care and Control Easy Again.
PMID: 27585381 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - August 31, 2016 Category: Respiratory Medicine Authors: Small PM Tags: Am J Respir Crit Care Med Source Type: research

Impact of Point-of-care Xpert MTB/RIF on Tuberculosis Treatment Initiation: A Cluster Randomised Trial.
CONCLUSIONS: POC positioning of Xpert led to more rapid initiation of appropriate TB treatment. Achieving one-stop diagnosis and treatment for all people with TB will require simpler, more sensitive diagnostics and broader strengthening of health systems. Clinical trial registration available at www.isrctn.com, ID ISRCTN18642314. PMID: 28727491 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 20, 2017 Category: Respiratory Medicine Authors: Lessells RJ, Cooke GS, McGrath N, Nicol MP, Newell ML, Godfrey-Faussett P Tags: Am J Respir Crit Care Med Source Type: research

Optimizing the Detection of Recent Tuberculosis Infection in Children in a High TB-HIV Burden Setting.
Conclusions: Where resources allow, use of interferon-gamma release assays should be considered in young, recently exposed, and HIV-infected children since they may offer advantages compared to the tuberculin skin test for identifying tuberculosis infection, and improve targeted, cost-effective delivery of preventive therapy. Affordable tests of infection could dramatically impact global tuberculosis control. PMID: 25622087 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 26, 2015 Category: Respiratory Medicine Authors: Mandalakas AM, Kirchner HL, Walzl G, Gie RP, Schaaf HS, Cotton MF, Grewal HM, Hesseling AC Tags: Am J Respir Crit Care Med Source Type: research

Intervening on Social Determinants for Better Outcomes in Pediatric Tuberculosis Management
Am J Respir Crit Care Med. 2023 Apr 19. doi: 10.1164/rccm.202303-0601LE. Online ahead of print.NO ABSTRACTPMID:37075314 | DOI:10.1164/rccm.202303-0601LE
Source: American Journal of Respiratory and Critical Care Medicine - April 19, 2023 Category: Respiratory Medicine Authors: Carlos Podalirio Borges de Almeida Carole Diane Mitnick Source Type: research

Reply to: Intervening on Social Determinants for Better Outcomes in Pediatric Tuberculosis Management
Am J Respir Crit Care Med. 2023 Apr 19. doi: 10.1164/rccm.202304-0629LE. Online ahead of print.NO ABSTRACTPMID:37075313 | DOI:10.1164/rccm.202304-0629LE
Source: American Journal of Respiratory and Critical Care Medicine - April 19, 2023 Category: Respiratory Medicine Authors: Leonardo Martinez Heather J Zar Source Type: research

Intervening on Social Determinants for Better Outcomes in Pediatric Tuberculosis Management
Am J Respir Crit Care Med. 2023 Apr 19. doi: 10.1164/rccm.202303-0601LE. Online ahead of print.NO ABSTRACTPMID:37075314 | DOI:10.1164/rccm.202303-0601LE
Source: American Journal of Respiratory and Critical Care Medicine - April 19, 2023 Category: Respiratory Medicine Authors: Carlos Podalirio Borges de Almeida Carole Diane Mitnick Source Type: research